The DNA Test That Helps Match You to the Right Chronic Pain Medications

One Test. Hundreds of Medications. A Smarter Way to Treat.

Chronic pain affects more than 50 million adults in the United States, according to the CDC. That means 1 in 5 Americans are living with ongoing pain that impacts their ability to work, sleep, and enjoy daily life. Yet for many, finding a treatment that works is a long and frustrating journey.

Pain is personal. So is how your body responds to pain medications.

Some patients get relief from nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen. Others rely on antidepressants, anticonvulsants, or opioid-based therapies to manage conditions like fibromyalgia, neuropathy, or back pain. But not everyone responds the same way, and side effects like sedation, gastrointestinal issues, or addiction risks are all too common.

PGx testing identifies those variations and provides a personalized medication roadmap.

When applied to chronic pain management, PGx can help avoid medications that won’t work for your body or that could trigger harmful side effects— such as respiratory depression with opioids or gastrointestinal bleeding with NSAIDs.

A 2023 review in Frontiers in Pharmacology found that PGx-guided pain treatment resulted in improved outcomes and fewer adverse events across several chronic pain studies.

How the BloomDNA® Test Works

BloomDNA® makes it easy to get actionable insights from home. Here’s how it works:

1. Receive your test kit in the mail
2. Use a quick cheek swab to collect your DNA sample
3. Mail it back in the prepaid return envelope
4. Your sample is analyzed in our CLIA-certified U.S. laboratory
5. Your provider receives a personalized medication report

The report includes recommendations for over 300 medications, including NSAIDs, muscle relaxants, antidepressants, anticonvulsants, and opioids commonly prescribed for chronic pain.

What the Test Can Reveal

BloomDNA® provides clear, clinically useful insights:

• Medications that may be ineffective based on your genetic profile
• Increased risk of side effects, such as nausea, drowsiness, or addiction
• Genetic variants that affect drug metabolism, like CYP2D6, which plays a key role in how you process opioids and antidepressants
• Recommendations for safer alternatives or dosage adjustments
• Insights into gene-drug interactions that may affect pain and mental health medications together

This is not a wellness test. BloomDNA® is designed for real-world clinical use.

Who Should Consider PGx Testing for Chronic Pain?

Pharmacogenetic testing can support pain management for:

• Patients starting new medications for pain
• Individuals with long-term conditions like fibromyalgia, arthritis, or sciatica
• People who have experienced side effects from NSAIDs, opioids, or nerve pain medications
• Patients with mental health conditions treated alongside pain
• Anyone taking multiple prescriptions and concerned about drug interactions

If you’ve tried more than one medication without success or are about to start treatment PGx testing can help clarify the best path forward.

A Long-Term Tool for Smarter Pain Management 

Your genetics don’t change, so the BloomDNA® test only needs to be taken once. The results can be used by your provider for years to come, whether you’re being treated for chronic pain, mental health, or other ongoing conditions. 

Take the Guesswork Out of Pain Medication

Chronic pain is already complicated. Your treatment shouldn’t add more uncertainty.

With BloomDNA®, your provider gains powerful insight into how your body is likely to respond to medications. That means less trial and error, fewer side effects, and a more personalized approach to relief.

Discover how BloomDNA® can support safer, more effective chronic pain treatment.